Pharmacologically Active Ingredients II

The Glucomannan System From Aloe Vahombe (Liliaceae) III. Comparative Studies On The Glucomannan Components Isolated From The Leaves Vilkas E; Radjabi-Nassab F Biochimie 68(9):1123-7 1986 Sep The polysaccharide mixture obtained by hot water extraction of Aloe vahombe leaves is composed of at least four different paritally acetylated glucomannans which differ in molecular weight, glucose to mannose ratios and acetyl contents. Furthermore, one fraction contains a small but significant amount of protein which could not be removed by gel filtration in a hydrogen-bond-breaking medium, by DEAE-Sephadex A-50 anion exchange chromatography, or by Sevag’s method. Orientation Of Interphase Chromosomes As Detected By Giemsa C-Bands Ghosh S; Roy SC Chromosoma 61(1):49-55 1977 Apr 27 The orientation of Giemsa C-bands has been studied in mitotic and interphase cells of Allium cepa. A sativum and of Aloe vera. The C-bands in these three species are located at the telomeres, secondary constriction region of the nucleolar chromosomes and the centromeric regions, respectively. Observations in A. cepa and Aloe indicate clearly that the interphase chromosomes are non-random in their orientation and possibly maintain their telophase configuration through the attachment of telomeres and perhaps of kinetochores with the nuclear membrane. Electron micrographs of onion cells also reveal that certain heterochromatic segments are associated with the nuclear membrane. The nucleolar interstitial C-bands in A. sativum remain free in the nucleoplasm and may come close to each other due to heterochromatic attraction. Such a heterochromatic attraction is also evident between telomeric regions and between centromeres. However, a two by two attachment could not be noticed. A diagrammatic representation of the orientation of interphase chromosomes has been presented. Purification Of Active Substances Of Aloe Arborescens Miller & Their Biological & Pharmacological Activity Saito, Hiroko Dep. Pharm., Aichi Cancer Center Phytother Res. (1993) 7 (Spec. Issue, Proceedings of the International Congress of Phytotherapy, 1991), S14-S19 The authors purified Aloctin A from Aloe arborescens Miller and defined its chem., biol. and pharmacol. activities. Aloctin A consists of two discrete bands, a and b with a combined S-S bond. Its mol. wt. for a is 7500 and the mol. wt. for b is 10,500. Aloctin A has many biol. and pharmacol. activities as follows: 1. hemagglutinating activity; 2. cytoagglutinating activity; 3. mitogenic activity of lymphocytes; 4. ppt. - forming reactivity with a2-macroglobulin; 5. complement C3 activating activity; 6. inhibition of heat-induced hemolysis of rat erythrocytes; 7. anti-tumor effect; 8. anti-inflammatory effect; 9. inhibition of gastric secretion and gastric lesions. The Molecular Structure Of Iso-Aloesin Isolated From The Leaves Of Aloe Vera L. Var. Chinensis (Haw.) Berge Yuan AX Guanxi Institute Of Traditional Chinese Medical & Pharmaceutical Sciences Chung Kuo Chung Yao Tsa Chih (1993 Oct) 18 (10) 609-11, 639 A new constituent iso-aloesin was isolated from the leaves of Aloe vera var. chinensis found in the Province of Guangxi. The molecular formula of iso-aloesin is C19H2209, which is 2-acetonyl-6-C-beta-D-glucopyranosyl-7-hydroxy-5-methyl-chromone.